Nature Artificial Sweetener Study Bogus, Says American Council on Science and Health

No SweetnersThe folks over at the invaluable science watchdog
group, the American Council on Science and Health, are calling foul
on the new Nature study purporting to show that three
different artificial sweetners boost blood glucose levels in mice
and in four of seven human research subjects. ACSH chemist Josh
Bloom suggests that it is very unlikley that three very different
chemical compounds that just happen to taste sweet,
sucralose
,
aspartame
, and
saccharin
, would all have the exact same biological effect.

ACSH
points out
:

Dr. Bloom explains, “The premise of this study—that artificial
sweeteners affect the microbial composition in the gut—makes
absolutely no sense chemically, physiologically, or
pharmacologically. The authors are taking chemicals that have
exactly one thing in common—sweetness—and trying to correlate this
with changes in gut bacteria that may be responsible for raising
blood sugar — and in mice, no less!.” …

What is the problem?

It is the absolute lack of any biologically plausible hypothesis
to explain, well, anything really.

Why is this?  Sweetness is a function of the interaction of
certain molecules with the sweet receptors on the tongue.

Dr. Bloom: “There is a wide variety of chemicals that are sweet,
both synthetic and naturally occurring.  They have exactly one
thing in common—taste. What can this possibly have to do with an
effect on gut bacteria? Nothing.

“The authors really should have dug up a chemist before they got
involved with this silly study. There are plenty of
us around—mostly unemployed. Because he/she would have pointed
out the gaping hole in the logic of the study—that you cannot group
a chemically diverse group of chemicals simply because they are
sweet, and draw any conclusion whatsoever about anything
other that the taste.

Dr. Bloom continues, “It might be possible (although still
highly unlikely) that any single sweet chemical could have
some effect on (you name it), but to then lump in other chemicals
that have nothing in common structurally or chemically is
ludicrous. You might as well take random chemicals out of a lab and
test them, because chemically, this is essentially what they
did.”

He adds. “As a chemist, if I saw a bunch of unrelated chemicals
doing the the same thing in a test, my mind would start screaming
‘the biology is a mess.’ This was borne out hundreds of times
during my career. It is one of the most important issues in drug
discovery—whether the biology makes sense.” …

“This just doesn’t add up. You could just as well group
chemicals together because they are yellow. It makes as much
sense.”

The researchers claim that fecal transplants with presumably
altered gut microflora from affected mice to naive mice produced
the same blood glucose spike. It should be easy enough to replicate
these experiments.

See my earlier and sadly more credulous blog on the study

here
. I did say that I would continue dose my
caffeinated beverages with Splenda.

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The Implications of Scottish Independence

The referendum polling stations are closed. By now, some three
million Scots will have had their say on whether Scotland should be
an independent country. There will be no exit polls and the votes
will be counted by hand. But sometime between midnight and 2 a.m.
Eastern Daylight Time, we should have a result.

The outcome is genuinely too close to call. The latest poll,

published
this morning by The Times of London, has the
“Better Together” campaign up by four points, 52–48 percent, with
four percent still undecided. But that, like most opinion polls in
recent days, is well within the margin for error. An upset is still
very possible.

But why would Scotland vote for independence, when 307 years of
union with England has served them—and the United Kingdom as a
whole—so well? What are the practical implications of a “Yes” vote?
And which side should libertarians be on? These questions bear some
examination, so read on if you want to know more.

Why would Scotland vote for independence?

First and foremost, it is worth remembering that Scotland
existed as a (mostly) independent country for more than 800 years
before its union with the Kingdom of England in 1707. And while the
English often use “English” and “British” interchangeably, there
has always existed a separate, distinctly Scottish sense of
national and cultural identity. As long as Britannia ruled the
waves, this identity was subsumed into a larger imperial project:
“wider still and wider, shall thy bounds be set.” But as Empire
crumbled and Continental threats faded, so too did that sense of
shared national purpose. Scottishness reasserted itself.

Natural resources played a role. Scottish nationalists claim
that the vast majority of the oil and gas in the North Sea
rightfully belongs to Scotland; “It’s Scotland’s Oil,” as the
campaign slogan goes. And, indeed, were the United Nations
Convention on the Law of the Sea’s “median line” approach to
dividing territorial waters adopted, around 80
percent
of the U.K.’s hydrocarbon production would fall under
Scottish jurisdiction. Wind turbines may be all the rage nowadays,
but black gold still has a powerful allure.

A third factor is political estrangement: Scotland has, for many
years, been drifting away from the rest of the U.K. The decline of
heavy industry hit Scotland hard, and Margaret Thatcher’s
Conservative government took most of the blame. Today,
Conservatives hold more than half of England’s parliamentary seats,
and the U.K. as a whole has a Conservative-led government. But
Scotland sends just one Conservative (from a total of 59
constituencies) to Westminster. The establishment of a Scottish
Parliament, responsible for most domestic policies and around 60
percent of public spending north of the border, has only hastened
this political detachment.

But perhaps the biggest factor driving the campaign for
independence is something that isn’t unique to Scotland—or even the
UK—at all. And that is deep distrust of a political elite that is
seen as venal, distant, and uninterested in the concerns of
ordinary people. Scottish nationalism is benefitting from the same
political forces boosting UKIP in England, the far-right in France,
the far-left in Greece, and the tea party in the United States.

Alex Salmond, Scotland’s nationalist first minister, has managed
to frame this referendum as one in which the people are facing up
against the political machine. The three Westminster
parties—Labour, Liberal Democrat, and Conservative—haven’t helped
matters by running a cynical, lackluster campaign in which
continued Union has seemed about as inspirational as a high-school
economics textbook. The nationalists are selling freedom, protest,
and self-determination; the unionists have fear and funding
formulas on their side.

What are the implications if Scotland does vote for
independence?

Most commentary on the prospects for an independent Scotland
have focused on the economic adjustment that Scotland will have to
make if it decides to go it alone. Given that it would start life
with one of the highest levels of gross domestic product (GDP) per
capita in the world, few doubt that Scotland could eventually
thrive on its own. But there is equally little doubt that the
transition would be a difficult one.

An independent Scotland’s first challenge would be fiscal.
The country’s 2012-13 budget deficit would have been 8.3 percent of
GDP, compared with 7.3 percent of GDP for the UK as a whole. And
while British budget deficits are on a downward trajectory, and
would be lower by the time Scotland officially became independent,
there would still be an awkward fiscal hole to fill.

What’s more, that 8.3 percent deficit figure depends on Scotland
receiving significant North Sea oil and gas revenues. If such
revenues are excluded, the deficit balloons to 14 percent of GDP.
This matters, because the North Sea hydrocarbon industry has been
in
decline
for some time, and such buoyant revenues may not last
for long. When you consider that Alex Salmond has promised to use
at least some of those revenues to create a sovereign wealth fund,
and also accept that Scotland faces a more rapidly aging population
(and correspondingly faster-rising welfare burdens) than the rest
of the U.K., it is clear that things could get worse, fiscally
speaking, before they get better.

Then there’s the issue of debt. Britain’s National Institute of
Economic and Social Research has
suggested
that Scotland’s share of the U.K. national debt would
amount to around 81 percent of GDP. That is bad, but by no means
unmanageable. But the issue is compounded in Scotland by
uncertainties about what currency the country will use after
independence.

The “Yes” campaign says Scotland will get a currency union with
the rest of the U.K. And while all three Westminster parties, along
with the Bank of England, have ruled that out during the referendum
campaign, it remains a practical possibility. Given that any
currency union would have to come with a fiscal pact placing strict
constraints on Scotland’s ability to run a budget deficit, and a
banking union ensuring that Scotland’s banks were closely
supervised by the U.K.’s financial regulators in return for
liquidity support from the Bank of England, it is unlikely that
Scotland’s borrowing costs would rise significantly in such a
scenario. The downside is that it may take the imposition of
unpopular austerity policies to keep an independent Scotland within
the boundaries of a fiscal pact with the U.K. Left-leaning “Yes”
voters who have been promised independence from a more conservative
England might be in for a nasty surprise.

And that assumes an independent Scotland would get the currency
union it desires. But let’s imagine the three Westminster parties
are true to their word, and Scotland is forced to adopt some other
currency arrangement. The events of the last few years have made
the euro a non-starter, and an independent Scotland wouldn’t
immediately be part of the European Union anyway. As a result, the
“Yes” campaign has said that, first, they would refuse to take any
share of the UK’s public debt if denied a currency union; and
second, they would continue to use the pound sterling unilaterally,
just as Panama, El Salvador, and Ecuador use the US dollar.

There are a couple of problems with this. For starters, refusing
to accept a share of the U.K.’s public debt could be viewed as an
effective default by the bond markets. That would mean an
independent Scotland would be forced to borrow money at very high
rates, or not at all. And whether that was the case or not,
Scotland would still be forced to accumulate significant foreign
exchange reserves to make “sterlingization” viable. Either of these
prospects would require an independent Scotland to make deep and
rapid cuts to public spending, so that they ran a budget surplus,
rather than a deficit. Once again, this is not the future that
independence supporters are voting for.

One more problem: under the “sterlingization” scenario—the
unilateral use of pound sterling as currency—Scotland wouldn’t have
a central bank to provide lender-of-last-resort facilities to its
banks, or to print money in the event that these banks needed to be
bailed out. This is hardly idle speculation: Scotland’s two biggest
banks—the Royal Bank of Scotland (RBS) and Halifax Bank of Scotland
(HBOS)—almost collapsed in 2008; saving them required a £65bn
bailout by the U.K. government. And that’s just the tip of the
iceberg: if you add in central bank liquidity support, government
guarantees for wholesale borrowing, and promises to protect
deposits, the government’s total exposure ran to the hundreds of
billions. The financial crisis would have sunk an independent
Scotland—especially one with no control over its currency.

This point may be moot, of course, since Scotland’s biggest
banks would probably relocate their headquarters to London at the
earliest opportunity if Scotland became independent and currency
union with the U.K. did not come to pass. But this raises yet
another unsavory possibility: bank deposits might follow the big
banks south of the border, as people try to escape the financial
uncertainty that independence could bring; this would force what
remained of the banking sector in Scotland to rapidly shrink its
balance sheet—that is, to scale back loans to businesses and
households—sparking a severe credit crunch that would surely plunge
Scotland into a painful recession. This doomsday scenario is by no
means beyond the realm of possibility.

Do libertarians have anything to say on Scottish
independence?

So far, this analysis has painted a pretty grim picture. And yet
libertarians might read it and wonder whether a wealthy,
independent country, which was forced to run a balanced budget,
which couldn’t print money, and which couldn’t bail out its banks,
would really be such a bad thing. In the long run, this may be
quite astute: most of the economic arguments against Scottish
independence stem from the fact that they impose hard constraints
on the size and scope of government, and from the libertarian
perspective, that is no bad thing.

Indeed, independence may be the best thing that could possibly
happen for the free market cause in Scotland. As things stand, any
tax cuts, spending reductions, or market-oriented reforms to public
services are seen as irredeemably foreign—something those dastardly
Tories in England might force on Scotland, but never something the
country would choose for itself. The existing, devolved Scottish
administration spends money, but doesn’t have responsibility for
raising it. Every incentive it has points in the direction of more
government, and those incentives matter.

Independence would change this dramatically: Scotland would be
forced to restructure its public sector, not just to reduce costs
in the short term, but also to deal with the prospect of an aging
population. It would have to adopt the most business-friendly
policies available to it, both to encourage enterprise at home, and
to bring in investment from overseas. And it would have to put in
place measures to ensure the stability and sustainability of its
financial sector, eliminating moral hazard in the process.
Sterlingization could even end up being a boon to an independent
Scotland. As my former colleagues at the Adam Smith Institute have
pointed
out
, it could usher in a new era of competitive free banking,
one in which the market—and not the central bank—spontaneously
adjusts the supply of money to ensure macroeconomic stability. This
is the stuff libertarian policy seminars are made of.

The effects of such a political turnaround would be felt beyond
Scotland. Their most immediate impact would be on the rest of the
U.K., which would be forced to up its game, but the lessons learned
in an independent Scotland could end up traveling far and wide. The
country that gave us David Hume and Adam Smith could once again be
a beacon of liberty, a case study in free minds and free markets.
Is that the most likely scenario? Perhaps not—and let there be no
doubt, if Scotland votes for independence tonight, there might be a
very rocky road ahead. But maybe, just maybe, it’s worth the
risk.

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First YouGov Poll Predicts The Scottish “No’s” Have It With 54% Of The Vote

With a reported turnout above 90% (over 4.2 million votes), YouGov reports its exit polls at…

  • *YOUGOV REFERENDUM PREDICTION: YES 46%, NO 54%

It appears, as somewhat expected, that Fife will be the key swing constituency.

 

 

*  *  *

GBP was pushing higher into the polls

*  *  *

Addiitional declaration times are throughout the evening…

 

With Credit Suisse guesstimates of YES/NO:

 

Rumors are active..

Remember…




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First YouGov Poll Predicts The Scottish "No's" Have It With 54% Of The Vote

With a reported turnout above 90% (over 4.2 million votes), YouGov reports its exit polls at…

  • *YOUGOV REFERENDUM PREDICTION: YES 46%, NO 54%

It appears, as somewhat expected, that Fife will be the key swing constituency.

 

 

*  *  *

GBP was pushing higher into the polls

*  *  *

Addiitional declaration times are throughout the evening…

 

With Credit Suisse guesstimates of YES/NO:

 

Rumors are active..

Remember…




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Alibaba Prices At $68: Here’s What Happens Next

The deal is done…

*ALIBABA SAID TO PRICE IPO AT $68: CNBC CITES DOW JONES

At that price, BABA is valued at ~$170 billion – higher than 95% of the S&P 500 and the biggest US IPO ever at $21.8 billion (bigger than Visa’s $19.7bn debut in 2008).

So if you want to buy some BABA shares, here’s what happens next…

The much anticipated Alibaba IPO will begin trading tomorrow under the symbol BABA. To ensure efficient execution of your orders, please be advised of the following:

  • Orders can only be entered after 4:00 pm today.
  • All orders entered to participate in the Open tomorrow require a Limit. No Market Orders will be accepted.
  • It is anticipated trading will commence at approx. 11 am EST; however, this time is dependent on NYSE bank instruction to its brokers

YHOO shares were rising into the news (after a weak day)…

 




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Alibaba Prices At $68: Here's What Happens Next

The deal is done…

*ALIBABA SAID TO PRICE IPO AT $68: CNBC CITES DOW JONES

At that price, BABA is valued at ~$170 billion – higher than 95% of the S&P 500 and the biggest US IPO ever at $21.8 billion (bigger than Visa’s $19.7bn debut in 2008).

So if you want to buy some BABA shares, here’s what happens next…

The much anticipated Alibaba IPO will begin trading tomorrow under the symbol BABA. To ensure efficient execution of your orders, please be advised of the following:

  • Orders can only be entered after 4:00 pm today.
  • All orders entered to participate in the Open tomorrow require a Limit. No Market Orders will be accepted.
  • It is anticipated trading will commence at approx. 11 am EST; however, this time is dependent on NYSE bank instruction to its brokers

YHOO shares were rising into the news (after a weak day)…

 




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You Know Your Country Is Broke When…

Submitted by Simon Black via Sovereign Man blog,

Imagine coming home from work and finding that a group of men have broken into your house. What do you do?

I have a gratified feeling that for an increasing number of our readers, the answer would be to draw their firearm and defend the home.

But it’s safe to say most folks would… call the police.

This happened in Greece recently, as recounted to me in an email by a colleague who was visiting his family in a rural, seaside town in the country’s southern mainland.

There’s recently been rash of home burglaries in the village– a remarkable turn of events for a place accustomed to leaving windows and doors unlocked.

In one instance, a local resident came home and spied a thief in progress; he immediately called the police to dispatch a unit as quickly as possible. And the police reportedly told the man, “We haven’t enough fuel to come out there right now.”

It shouldn’t come as a surprise to hear that public services are being cut back in Greece given how messed up their economy is.

But protecting citizens against crime is supposedly one of the sacrosanct terms of the social contract.

Citizens around the world have exchanged their freedom for security. It’s a completely absurd trade. . . but nevertheless it’s happened.

And in doing so, governments have essentially monopolized the security business. By and large, police and security are public services provide exclusively by the government.

And supposedly the taxes that we all pay go to fund those services. . . ensuring that someone from the government will come and ‘save’ us when the bad guys approach.

That’s the promise, at least.

But in difficult economic times, bankrupt governments routinely set aside promises they’ve made to taxpayers.

They slash pension (social security) benefits or use funky gorilla math to understate cost of living increases.

They completely violate the sacred vow of maintaining a strong, sound currency.

And they drastically reduce or even eliminate funding for critical services that people have come to depend on.

Of course, this situation isn’t unique to Greece. Every bankrupt nation reaches this point sooner or later.

Recently in [bankrupt] Argentina, a single police officer was left in charge of an entire jail in the Buenos Aires area which was housing several dozen prisoners.

The lone officer, who was clearly in over her head and poorly trained, heard suspicious noises somewhere in the building. So what did she do? She (a police officer) called the police.

Argentine media has published a recording of the officer’s 911 call, where the emergency dispatcher told the officer to get a colleague to ‘try and stop by.’

Oh hey, I hope you’re not too busy issuing parking tickets and providing security for thieving politicians– would you mind making sure we don’t have a prison break on our hands?

But the police officer’s response really reveals just how desperate the situation is, “I have only one vehicle to patrol the whole district.”

Again, these aren’t isolated events. This is a major trend that is due to befall any bankrupt government.

Think about it: are we really so arrogant to believe that a bankrupt government can continue to borrow money forever without consequence?

Bottom line: independence is key. You cannot rely on a bankrupt government to provide the services that they promise.

That goes for anything… from providing basic security to insuring bank deposits to paying out Social Security benefits.

They simply don’t have the financial means to make good on their promises.

And this is a reality that’s important to recognize and prepare for before it’s too late.




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Larry Ellison Steps Down As CEO Of Oracle

Unlike Steve Jobs, who almost literally passed away engrossed by his lifetime legacy, his work, that “other” billionaire, Oracle’s Larry Ellison, 70 years young, has decided to step aside and focus on the more enjoyable things in life, such as buying Hawaiian islands.

In his departure, he will be appointed to the title of Executive Chairman, and is replaced by Mark Hurd and Safra Catz as joint CEOs of the company.

Just out from the company:

The Oracle Board of Directors today announced that it has elected Larry Ellison to the position of Executive Chairman of Oracle’s Board and appointed him the company’s Chief Technology Officer. Jeff Henley, who has served as Oracle’s Chairman for the last 10 years, was appointed Oracle’s Vice Chairman of the Board.

 

The Oracle Board also promoted both Safra Catz and Mark Hurd to the position of CEO, Oracle Corporation. All manufacturing, finance, and legal functions will continue to report to Oracle CEO, Safra Catz. All sales, service and vertical industry global business units will continue to report to Oracle CEO, Mark Hurd. All software and hardware engineering functions will continue to report to Oracle Chairman and CTO, Larry Ellison.

 

“Safra and Mark will now report to the Oracle Board rather than to me,” said Larry Ellison. “All the other reporting relationships will remain unchanged. The three of us have been working well together for the last several years, and we plan to continue working together for the foreseeable future. Keeping this management team in place has always been a top priority of mine.”

 

“Larry has made it very clear that he wants to keep working full time and focus his energy on product engineering, technology development and strategy,” said the Oracle Board’s Presiding Director, Dr. Michael Boskin. “Safra and Mark are exceptional executives who have repeatedly demonstrated their ability to lead, manage and grow the company. The Directors are thrilled that the best senior executive team in the industry will continue to move the company forward into a bright future.”

But don’t cry for Larry: since he owns about 25% of the company, now that Oracle just announced another $13 billion buyback authorization, Larry will get just over $3 billion of that in the coming several quarters.




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S&P Hits All-Time Record High As Russell “Death Cross” Looms

For the first time since July 2011's plunge, and with almost half its components already in bear market, the Russell 2000 looks set to experience a 'death cross' in the next few days (50-day moving average crossing below the 200-day). But don't look at that – the S&P 500 and Dow hit new record highs (despite market internals slumping) today ahead of the BABA IPO to keep the dream alive just a little longer ahead of tomorrow's quad-witching malarkey. Today's action was dominated by dismal housing data (demolishing yesterday's exuberance in homebuilders), Poroshenko's "Ukraine invasion" headlines, and hopes ahead of BABA and Scottish votes. USD down on the day, commodities down, bonds unch, stocks… UP.

 

Russell 2000 Nears Death Cross…

As market internals collapse…

With "Most Shorted" stocks dumped into the afternoon…after the big squeeze open…

 

Since the FOMC statement, things changed quickly for homebuilders…

 

And financials were the post-FOMC big winners – but credit continues to ignore that relative exuberance…

 

Just like last time…

 

Gold ansd silver were smashed early on but bounced back after Poroshenko's "Russia has invaded Ukraine" statement to The US Congress…

 

And while stocks bounced back from the initial plunge, they struggled to hold post-Poroshenko gains… before the utter buying panic that happened in the last hour

 

And on the week, while The Dow surges, Russell 2000 managed to get to unch after the usual late-day buying panic saved the day…

 

Treasury Yields stabilized today after the post FOMC kneejerk  – unchanged…

 

Credit weakened into the close…

 

FX markets saw USD weakness on the day, giving back most of the post-FOMC gains.. on EUR/GBP strength outweighing JPY weakness…

 

USD Up, Stocks Up becomes USD Down, Stocks Up…

 

Commodities dropped on the day – despite USD weakness…

 

Stocks caught up to USDJPY's overnight ramp… led by AUDJPY all day again…

 

As both WTI and Brent slipped…

 

Charts: Bloomberg

Bonus Chart: While GBP vol is heavily bid, the modest recovery in cable today suggest traders think a "no" vote is coming – but don't seem convinced relative to the decline…

And here's how undecideds made up their minds…

 




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S&P Hits All-Time Record High As Russell "Death Cross" Looms

For the first time since July 2011's plunge, and with almost half its components already in bear market, the Russell 2000 looks set to experience a 'death cross' in the next few days (50-day moving average crossing below the 200-day). But don't look at that – the S&P 500 and Dow hit new record highs (despite market internals slumping) today ahead of the BABA IPO to keep the dream alive just a little longer ahead of tomorrow's quad-witching malarkey. Today's action was dominated by dismal housing data (demolishing yesterday's exuberance in homebuilders), Poroshenko's "Ukraine invasion" headlines, and hopes ahead of BABA and Scottish votes. USD down on the day, commodities down, bonds unch, stocks… UP.

 

Russell 2000 Nears Death Cross…

As market internals collapse…

With "Most Shorted" stocks dumped into the afternoon…after the big squeeze open…

 

Since the FOMC statement, things changed quickly for homebuilders…

 

And financials were the post-FOMC big winners – but credit continues to ignore that relative exuberance…

 

Just like last time…

 

Gold ansd silver were smashed early on but bounced back after Poroshenko's "Russia has invaded Ukraine" statement to The US Congress…

 

And while stocks bounced back from the initial plunge, they struggled to hold post-Poroshenko gains… before the utter buying panic that happened in the last hour

 

And on the week, while The Dow surges, Russell 2000 managed to get to unch after the usual late-day buying panic saved the day…

 

Treasury Yields stabilized today after the post FOMC kneejerk  – unchanged…

 

Credit weakened into the close…

 

FX markets saw USD weakness on the day, giving back most of the post-FOMC gains.. on EUR/GBP strength outweighing JPY weakness…

 

USD Up, Stocks Up becomes USD Down, Stocks Up…

 

Commodities dropped on the day – despite USD weakness…

 

Stocks caught up to USDJPY's overnight ramp… led by AUDJPY all day again…

 

As both WTI and Brent slipped…

 

Charts: Bloomberg

Bonus Chart: While GBP vol is heavily bid, the modest recovery in cable today suggest traders think a "no" vote is coming – but don't seem convinced relative to the decline…

And here's how undecideds made up their minds…

 




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